| Palindromic Rheumatoid Arthritis Research Information and Support group. | |||||||
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| TRADITIONAL MEDICATIONS: | ||||
| During attacks associated with Palindromic Rheumatoid Arthritis (PRA) nonsteroidal anti-inflammatory drugs (NSAIDs) are often prescribed. Disease-modifying anti-rheumatic drugs (DMARDs) and COLCHICINE are sometimes prescribed to prevent future attacks of Palindromic Rheumatoid Arthritis (PRA). The use of anti-malarial drugs (eg PLAQUENIL) in patients with Palindromic Rheumatoid Arthritis (PRA) has been associated with decreased risk of developing rheumatoid arthritis or other connective tissue diseases, according to a study published in the January 2000 issue of the Journal of Rheumatology | ||||
| NSAIDs / COX-2 Inhibitors NSAIDs (nonsteroidal anti-inflammatory drugs) are among the most commonly prescribed and widely used arthritis drugs. There are three types of NSAIDs: salicylates (both acetylated, such as aspirin, and nonacetylated such as (Disalcid) salsalate, (Trilisate) choline magnesium trisalicylate and (Doan's Pills, Novasal) magnesium salicylate), the traditional NSAIDs, and COX-2 selective inhibitors. NSAIDs work by blocking the activity of the enzyme, cyclooxygenase, also known as COX. Research has revealed that there are two forms, known as COX-1 and COX-2. NSAIDs affect both forms. COX-1 is involved in maintaining healthy tissue, while COX-2 is involved in the inflammation pathway. COX-2 selective inhibitors became a new subset of NSAIDs born of this research. |
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| Traditional NSAIDs include: • Ansaid (Flurbiprofen) • Arthrotec (Diclofenac/Misoprostol) • Cataflam (Diclofenac potassium) • Clinoril (Sulindac) • Daypro (Oxaprozin) • Dolobid (Diflunisal) • Feldene (Piroxicam) • Ibuprofen (Motrin, Advil) • Indocin (Indomethacin) • Ketoprofen (Orudis, Oruvail) • Lodine (Etodolac) • Meclomen (Meclofenamate) • Mobic (Meloxicam) • Nalfon (Fenoprofen) • Naproxen (Naprosyn, Aleve) • Ponstel (Mefanamic Acid) • Relafen (Nabumetone) • Tolectin (Tolmetin) • Voltaren (Dicolfenac Sodium) |
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| COX-2 Inhibitors include: • Celebrex (Celecoxib) • Vioxx (Rofecoxib)(no longer on market) • Bextra (Valdecoxib)(no longer on market) |
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| DMARDs DMARDs (Disease-Modifying Anti-Rheumatic Drugs) have also been labeled "slow-acting anti-rheumatic drugs" (because they take weeks or months to work) and "second-line agents". However, research has shown the effectiveness of DMARDs in the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis and the importance of early, aggressive treatment with these drugs. For some, these drugs can stop disease progression and halt joint damage. |
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| DMARDs include: • Arava (Leflunomide) • Auranofin (Ridaura, Oral Gold) • Azulfidine (Sulfasalazine) • Mycophenolate (CellCept) • Myochrysine (Injectable Gold) • Cyclosporine (Neoral,Sandimmune) • Cytoxan (Cyclophosphamide) • Imuran (Azathioprine) • Leukeran (Chlorambucil) • Methotrexate (Rheumatrex, Trexall) • Minocin (Minocycline) • Penicillamine (Cuprimine, Depen) • Plaquenil (Hydroxychloroquine) |
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| CORTICOSTEROIDS (Steroids) ANALGESICS (Pain Killers) Analgesics are pain relieving drugs. Controlling pain is a vital part of treating arthritis. However, unlike NSAIDs, analgesics do not relieve inflammation. Acetaminophen (Tylenol) is the most commonly used analgesic. |
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| ARCOTIC ANALGESIC DRUGS (can also be
prescribed for severe pain) Narcotics include: • Codeine (Tylenol#3) • Darvocet (Propoxyphene/Acetaminophen) • Darvon (Propoxyphene) • Duragesic (Fentanyl Skin Patch) • Morphine Sulphate (MS Contin) • Oxycodone (OxyContin) • Percocet (Oxycodone/Acetaminophen) • Percodan ( Oxycodone/ Aspirin) • Talwin NX (Pentazocine/Naloxone) • Ultracet (Tramadol/Acetaminophen) • Ultram (Tramadol) • Vicodin (Hydrocodone/Acetaminophen) |
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